Drug intelligence / Profile preview

mistletoe resinous extract

Development stage
Preclinical
Lead developer
Verein für Krebsforschung
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Subcutaneous, Intravenous, Intratumoral, Intracavitary, Intramuscular, Intracutaneous
01

Overview

Mistletoe resinous extract is a botanical extract derived from the European mistletoe (*Viscum album*), currently in preclinical development by the Verein für Krebsforschung (VfK). While traditional mistletoe preparations used in integrative oncology are typically aqueous extracts, this resinous formulation is specifically designed to capture lipophilic components of the plant, such as triterpene acids, which are poorly soluble in water. The extract is intended for use as an integrative or complementary treatment for cancer, where it is reported to exert cytotoxic and immunomodulatory effects. Research by VfK is focused on characterizing the pharmaceutical properties of these resinous components to expand the therapeutic range of mistletoe-based oncology treatments.

Other names
Viscum album resinous extractresinous mistletoe extract
02

Targets

FOXM1 (Forkhead box protein M1)Cell-surface carbohydrate motifF10 (Factor Xa)BTN3A1 (Butyrophilin 3A1/2A1 complex)28S rRNA (28S ribosomal RNA)STAT3 (Signal Transducer and Activator of Transcription 3)

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