Drug intelligence / Profile preview

miswak extract

Development stage
Phase 4
Modality
Small Molecules, Peptides
Administration
Topical
01

Overview

Miswak extract is a natural botanical substance derived from the roots, twigs, or stems of the *Salvadora persica* tree, also known as the toothbrush tree. Traditionally used for centuries as a natural chewing stick (miswak), the extract contains a complex array of bioactive compounds including silica, tannins, saponins, flavonoids, alkaloids, and sulfur. In modern dentistry, it is utilized for its potent antimicrobial, anti-inflammatory, anti-cariogenic, and antioxidant properties. Clinically, it has been investigated in various formulations, such as mouthwashes, toothpastes, dental varnishes, and as an additive to glass ionomer cements (GIC). Its therapeutic utility spans the reduction of dental plaque and gingival inflammation, the management of oral malodor (halitosis), and the treatment of dentine hypersensitivity through the physical blocking of dentinal tubules and inhibition of collagenase activity.

Brand names
Persica
Other names
Salvadora persica extractS. persica extractmiswak root extractaqueous miswak extractethanolic miswak extractHoggar Salvadora persica extract
02

Targets

COL1 (Collagen type I)Dentinal matrix metalloproteinases

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