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Miswak extract is a natural botanical substance derived from the roots, twigs, or stems of the *Salvadora persica* tree, also known as the toothbrush tree. Traditionally used for centuries as a natural chewing stick (miswak), the extract contains a complex array of bioactive compounds including silica, tannins, saponins, flavonoids, alkaloids, and sulfur. In modern dentistry, it is utilized for its potent antimicrobial, anti-inflammatory, anti-cariogenic, and antioxidant properties. Clinically, it has been investigated in various formulations, such as mouthwashes, toothpastes, dental varnishes, and as an additive to glass ionomer cements (GIC). Its therapeutic utility spans the reduction of dental plaque and gingival inflammation, the management of oral malodor (halitosis), and the treatment of dentine hypersensitivity through the physical blocking of dentinal tubules and inhibition of collagenase activity.
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