mite allergen extract

Mite allergen extract is a biological product used in allergen-specific immunotherapy (AIT) for the treatment of house dust mite (HDM)-induced allergic rhinitis and allergic asthma. It typically consists of a standardized mixture of allergens from the dust mite species *Dermatophagoides pteronyssinus* and *Dermatophagoides farinae*. The mechanism involves modulating the patient's immune system to induce allergen-specific tolerance, primarily by shifting the immune response from a Th2-mediated (allergic) profile to a Th1/Treg-mediated profile. This shift reduces IgE-mediated responses and increases the production of protective IgG4 antibodies and regulatory cytokines such as IL-10. It is administered via subcutaneous injection (SCIT) or sublingual (SLIT) routes. Recent research, including studies at Renji Hospital, explores its potential impact on comorbid hyperactivity symptoms in patients with respiratory allergies.

Brand names

AcarizaxOdactraActairAlutard SQ

Other names

house dust mite allergen extractHDM allergen extractmite allergen-specific immunotherapy