mito-TEMPO

mito-TEMPO is a mitochondria-targeted antioxidant small molecule designed to accumulate within mitochondria and scavenge reactive oxygen species (ROS), particularly superoxide and alkyl radicals. It consists of the piperidine nitroxide TEMPO moiety conjugated to a triphenylphosphonium cation for mitochondrial targeting. By reducing mitochondrial oxidative stress, mito-TEMPO protects against cellular damage in various models of disease including acetaminophen-induced hepatotoxicity, N-nitrosodiethylamine-induced hepatocarcinogenesis in mice, renal fibrosis, ischemic brain injury, and noise-induced hearing loss. Its mechanism involves mimicking superoxide dismutase activity within mitochondria and preventing ROS-mediated damage to mitochondrial components[1][2][3][5][7]. It is used primarily as a research tool in both in vitro and in vivo studies.

Brand names

mito-TEMPO

Other names

(2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride