mitochromanol-acetate

Mitochromanol-acetate (also known as Mito-ChMAc or MitoCA) is a mitochondria-targeted vitamin E (chromanol) analog conjugated to a triphenylphosphonium (TPP+) cation via a 10-carbon alkyl linker. Developed as an experimental therapeutic agent, it selectively accumulates in the mitochondrial inner membrane of cancer cells due to their hyperpolarized mitochondrial membrane potential. Although originally designed as a mitochondria-targeted antioxidant, mitochromanol-acetate exhibits pro-oxidant activity in cancer cells, inducing mitochondrial depolarization, increasing mitochondrial superoxide production, depleting intracellular ATP, and inhibiting mitochondrial respiration. This selective mitochondrial dysfunction triggers mitophagy and apoptosis, making it a promising candidate for the treatment of triple-negative breast cancer and small cell lung cancer.

Other names

mitochandria-targeted chromanol acetatemitochondria-targeted vitamin E acetatemitochromanol acetatemitochromanol-acetate