mitomycin c

Mitomycin C is an antitumor antibiotic and chemotherapy agent derived from the bacterium Streptomyces caespitosus. It acts as a bioreductive alkylating agent, becoming activated in vivo to form bifunctional and trifunctional alkylating species that cross-link DNA, thereby inhibiting DNA synthesis and function. This leads to cell death, particularly in rapidly dividing cancer cells. At higher concentrations, it can also suppress RNA and protein synthesis. Mitomycin C is cell cycle phase-nonspecific but has maximal effect in late G1 and early S phases. It is primarily indicated for the treatment of various cancers including gastric (stomach), pancreatic, bladder (intravesical or upper tract), anal, breast, head and neck cancers, among others[2][3][4][5][8]. The drug may be administered intravenously or directly into the bladder or urinary tract depending on indication.

Brand names

MutamycinMitomycin-CMitosolJelmytoAlmitoMitocinOncocinMitodus

Other names

mitomycin cmitomycin-Cmitomycin (sometimes used interchangeably)ameticyne