Drug intelligence / Profile preview

mitomycin c + epirubicin + cisplatin

Development stage
Preclinical
Lead developer
Kyowa Kirin
Modality
Small Molecules
Administration
Intravenous
01

Overview

A combination chemotherapy regimen consisting of **mitomycin C**, **epirubicin**, and **cisplatin**, each of which belongs to a different class of antineoplastic agents. Mitomycin C is an alkylating agent with DNA cross-linking activity, epirubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II, and cisplatin is a platinum-based compound that causes DNA cross-linking and apoptosis. This combination is designed for synergistic anti-tumor effects and is primarily investigated for treatment of various solid tumors, though there are no established standard protocols for this exact combination.

02

Targets

TOP2A (DNA topoisomerase II)DNA

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