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mitomycin C + mitoxantrone
- Development stage
- Unknown
- Lead developer
- UroGen Pharma
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of mitomycin C and mitoxantrone used primarily for the treatment of advanced breast cancer. This combination has shown activity against breast cancer with varying response rates across studies. It is generally associated with mild hematological toxicity and minimal gastrointestinal side effects and alopecia compared to other chemotherapy regimens, though serious adverse events including hemolytic-uremic syndrome, pulmonary fibrosis, and hepatic failure have been reported.
02
Targets
DNATOP2A (DNA topoisomerase II)TOP2B (DNA topoisomerase II beta)
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