Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
mitraphylline
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Mitraphylline is a pentacyclic oxindole alkaloid primarily isolated from the inner bark of Uncaria tomentosa (Cat's Claw), a plant native to South America. It has demonstrated significant antiproliferative and cytotoxic activities in various human cancer cell lines, including Ewing's sarcoma (MHH-ES-1) and breast cancer (MT-3), by inhibiting cell growth in a dose-dependent manner. Research suggests it may also possess anti-inflammatory properties by modulating cytokine production, specifically through the inhibition of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1B). While it is a key bioactive component in traditional herbal preparations, mitraphylline is primarily studied as a research compound for its potential oncological and anti-inflammatory therapeutic applications.
- Other names
- mitraphylline
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)IL1B (Interleukin-1 beta)
Beyond the preview
Go deeper on mitraphylline.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on mitraphylline.