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Drug intelligence / Profile preview
mitraphylline
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Mitraphylline is a pentacyclic oxindole alkaloid primarily isolated from the inner bark of Uncaria tomentosa (Cat's Claw), a plant native to South America. It has demonstrated significant antiproliferative and cytotoxic activities in various human cancer cell lines, including Ewing's sarcoma (MHH-ES-1) and breast cancer (MT-3), by inhibiting cell growth in a dose-dependent manner. Research suggests it may also possess anti-inflammatory properties by modulating cytokine production, specifically through the inhibition of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1B). While it is a key bioactive component in traditional herbal preparations, mitraphylline is primarily studied as a research compound for its potential oncological and anti-inflammatory therapeutic applications.
- Other names
- mitraphylline
02
Targets
IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))
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