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Miuri Tandem
- Development stage
- Unknown
- Lead developer
- Bio-STILOGIT Pharmaceuticals
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Miuri Tandem is a multi-ingredient dietary supplement developed by Bio-STILOGIT Pharmaceuticals, primarily marketed in Italy for the management of urinary tract health and the prevention of recurrent urinary tract infections (UTIs), such as cystitis. The formulation typically combines D-mannose with botanical extracts, including Cranberry (Vaccinium macrocarpon) and Bearberry (Arctostaphylos uva-ursi). D-mannose acts as a competitive inhibitor of bacterial adhesion by binding to the FimH adhesins of *Escherichia coli*, preventing the bacteria from colonizing the urothelium and facilitating their clearance through urination. Cranberry proanthocyanidins (PACs) provide a complementary anti-adhesive effect, while Bearberry contains arbutin, which is metabolized to hydroquinone in the urine to exert antimicrobial properties. The product is sold as a retail consumer health product rather than a prescription pharmaceutical.
- Brand names
- Miuri Tandem
02
Targets
FimH (Type 1 fimbrial adhesin)
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