Drug intelligence / Profile preview

mivacurium

Development stage
Phase 4
Lead developer
GSK
Modality
Small Molecules
Administration
Intravenous
01

Overview

Mivacurium is a short-acting, non-depolarizing neuromuscular blocking agent used to induce skeletal muscle relaxation during surgical procedures or while on mechanical ventilation. It acts as a competitive antagonist at nicotinic acetylcholine receptors on the motor endplate, inhibiting the action of acetylcholine and thereby blocking neuromuscular transmission. Mivacurium is hydrolyzed by plasma cholinesterase, resulting in rapid recovery after discontinuation. Its primary indications are for facilitating tracheal intubation and providing muscle relaxation during surgery or mechanical ventilation[1][2][3][4][5][6].

Brand names
Mivacron
Other names
mivacurium chloridemivacurium
02

Targets

CHRM2 (M2)Nicotinic Acetylcholine ReceptorCHRM3 (M3)

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