mixed amphetamine salts

**Mixed amphetamine salts** is an oral central nervous system stimulant comprising equal salt-weight proportions of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, and amphetamine sulfate, yielding a 3:1 dextroamphetamine-to-levoamphetamine ratio. It increases synaptic catecholamine signaling primarily by acting as a substrate at dopamine and norepinephrine transporters, promoting monoamine release and reducing transporter-mediated reuptake; vesicular monoamine transporter 2 and trace amine-associated receptor 1 also contribute to its pharmacology. It is marketed in immediate-release and extended-release products for attention-deficit/hyperactivity disorder, and immediate-release mixed amphetamine salts is also approved for narcolepsy. It is a Schedule II controlled substance in the United States with substantial risks of misuse, abuse, dependence, insomnia, appetite suppression, and cardiovascular effects.

Brand names

AdderallAdderall XRMydayis

Other names

amphetamine mixed saltsMASmixed amphetamine saltsmixed salts of a single-entity amphetamine product