mixed amphetamine salts (Takeda, 0454e2)

Mixed amphetamine salts is a central nervous system (CNS) stimulant composed of four different amphetamine salts: dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, and amphetamine sulfate. It is primarily indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. The drug works by increasing the synaptic concentrations of norepinephrine and dopamine through several mechanisms: it acts as a competitive inhibitor of the dopamine transporter (DAT) and norepinephrine transporter (NET), promotes the release of these neurotransmitters from presynaptic neurons, and inhibits their sequestration into vesicles via the vesicular monoamine transporter 2 (VMAT2). Additionally, it acts as an agonist at the trace amine-associated receptor 1 (TAAR1). The mixture typically contains a 3:1 ratio of dextroamphetamine to levoamphetamine isomers, which is intended to provide a balanced therapeutic effect on focus and alertness while managing peripheral side effects.

Brand names

AdderallAdderall XRMydayisAdzenys XR-ODTDyanavel XR

Other names

MASMAS-XRamphetamine salt comboamphetamine aspartate/amphetamine sulfate/dextroamphetamine saccharate/dextroamphetamine sulfate