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Mixtard 30 is a biphasic human insulin preparation consisting of 30% soluble insulin (short-acting) and 70% isophane insulin (intermediate-acting). It is used to manage blood glucose levels in patients with diabetes mellitus by mimicking the physiological insulin response. The soluble component provides a rapid onset of action to control postprandial glucose spikes, while the isophane component provides a prolonged effect to maintain basal insulin levels. In the clinical trial context provided, Hospital Sultanah Aminah Johor Bahru is evaluating the efficacy and safety of a thrice-daily (TDS) dosing regimen of Mixtard 30 compared to standard basal-bolus therapy in patients with poorly controlled type 2 diabetes mellitus. The drug is developed and manufactured by Novo Nordisk and is widely approved for the treatment of both type 1 and type 2 diabetes.
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