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MK-0557 + sibutramine

Development stage: Unknown
Lead developer: Merck
Modality: Small Molecules
Administration: Oral

Overview

This combination involves **MK-0557**, a potent and selective antagonist of the Neuropeptide Y5 receptor (NPY5R), and **sibutramine**, a centrally acting stimulant chemically related to amphetamines, used as an oral anorexiant. The combination was studied for its potential in treating obesity by enhancing weight loss efficacy. However, clinical trials showed that adding MK-0557 to sibutramine did not significantly increase weight loss compared to sibutramine alone[1][2].

Brand names: sibutramine
Other names: mk-0557 + sibutraminesibutramine hydrochloride + MK-0557

Targets

SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)NPY5R (Neuropeptide Y receptor type 5)

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