Drug intelligence / Profile preview

MK-6592

Development stage: Discontinued
Lead developer: Merck
Modality: Small Molecules

Overview

MK-6592 is a small molecule aurora kinase inhibitor that was developed for the treatment of cancer, specifically solid tumors. Aurora kinases are enzymes involved in cell division, and their aberrant expression has been linked to cancer progression. By inhibiting these kinases, MK-6592 aimed to disrupt tumor cell proliferation. The drug was originally discovered by Vertex Pharmaceuticals and further developed by Merck & Co., but its development was discontinued after it failed to meet pharmacokinetic objectives in Phase 1 clinical trials for solid tumors.

Targets

AURKA (Aurora kinase A)AURKB (Aurora kinase B)AURKC (Aurora kinase C)AURK (Aurora kinase family)

Beyond the preview

Go deeper on MK-6592.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on MK-6592.