ML162

ML162 is a small molecule covalent inhibitor primarily known for targeting glutathione peroxidase 4 (GPX4), an essential selenoprotein that protects cells from lipid peroxidation and ferroptosis. By inhibiting GPX4, ML162 induces ferroptosis—a form of regulated cell death characterized by iron-dependent accumulation of lipid peroxides. This compound is selectively lethal to mutant RAS oncogene-expressing cell lines and has been widely used as a tool compound in research on ferroptosis and redox biology[1][3][5]. Recent studies suggest that while traditionally classified as a GPX4 inhibitor, ML162 may also inhibit thioredoxin reductase 1 (TXNRD1), indicating additional mechanisms beyond direct GPX4 inhibition[6]. It is not approved for clinical use and is intended for laboratory research only.

Other names

ML162ML-162ML 162CID 3689413CID3689413CID-3689413