MM07

MM07 is a synthetic cyclic peptide and a novel biased agonist of the apelin receptor (APJ/APLNR). It was designed using molecular dynamics simulations as an analogue of the endogenous ligand [Pyr(1)]apelin-13 to selectively activate G-protein signaling pathways while exhibiting significantly reduced recruitment of β-arrestin (approximately 350- to 1300-fold bias). By favoring G-protein coupling, MM07 promotes beneficial cardiovascular effects such as vasodilation and positive inotropy while avoiding β-arrestin-mediated receptor internalization and potentially detrimental signaling. In first-in-human clinical studies, MM07 demonstrated superior efficacy in increasing cardiac output and forearm blood flow compared to endogenous apelin. It is primarily being developed for the treatment of pulmonary arterial hypertension (PAH) and chronic heart failure.

Other names

Cyclic apelin-13 analogue