MMP-7 shRNA

MMP-7 shRNA is a **short hairpin RNA-based therapeutic** designed to silence the expression of matrix metalloproteinase-7 (MMP-7), a proteolytic enzyme involved in extracellular matrix degradation. MMP-7 shRNA functions through RNA interference mechanisms to reduce MMP-7 mRNA and protein levels in target cells. Research has demonstrated that MMP-7 plays critical roles in cancer progression, metastasis, drug resistance, and fibrosis. In preclinical studies, MMP-7 shRNA has shown efficacy in reducing tumor cell invasion, migration, and metastatic potential in cancer models[1][3]. Additionally, MMP-7 shRNA delivered via lentiviral vectors has demonstrated therapeutic benefit in attenuating subpleural lung fibrosis in animal models of rheumatoid arthritis-associated interstitial lung disease (RA-ILD)[4]. The mechanism involves knockdown of MMP-7 expression, which subsequently reduces collagen-I synthesis and prevents fibrotic tissue remodeling. In cancer contexts, MMP-7 knockdown decreases drug efflux activity, inhibits cell proliferation, reduces angiogenic potential, and suppresses invasive capabilities of tumor cells[1]. Studies show that MMP-7 shRNA can reduce tube formation, wound closure ability, and overall metastatic progression in vitro and in vivo[1][4].

Other names

MMP7 shRNAMMP-7 shRNAMMP 7 shRNAMatrix metalloproteinase-7 shRNAshRNA MMP7