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MNE-C261
- Development stage
- Preclinical
- Lead developer
- myNEO Therapeutics
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
MNE-C261 is an off-the-shelf mRNA-based cancer vaccine being developed by myNEO Therapeutics for the treatment of microsatellite-stable colorectal cancer (MSS-CRC). The vaccine utilizes myNEO's proprietary Camyotopes platform, which identifies and incorporates shared neoantigens (neoepitopes) that are frequently presented by tumor cells across a patient population. By delivering these antigens via mRNA, MNE-C261 aims to stimulate a robust T-cell mediated immune response against the tumor. As of 2024, the program is in the preclinical stage, with an Investigational New Drug (IND) or Clinical Trial Application (CTA) filing targeted for the first half of 2027.
02
Targets
Major histocompatibility complex class I and class II peptide-binding groovesTCR-Camyotope-pMHC (T-cell receptor recognizing Camyotope peptide–MHC complex)
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