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MNP-VERU
- Development stage
- Preclinical
- Lead developer
- University of Tennessee
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
MNP-VERU is a nanoparticle formulation of the tubulin inhibitor VERU-111 (sabizabulin). It consists of magnetic nanoparticles (MNPs) loaded with VERU-111, designed to enhance the delivery, bioavailability, and therapeutic index of the drug in the treatment of pancreatic cancer. The formulation targets beta-III and beta-IV tubulin isoforms, which are often overexpressed in drug-resistant tumors. By inhibiting these tubulin subunits and modulating miR-200c expression, MNP-VERU disrupts microtubule assembly, leading to cell cycle arrest and apoptosis. Preclinical studies have demonstrated that MNP-VERU is more effective than the free drug in suppressing pancreatic cancer cell growth and reducing tumor volume in xenograft models.
- Other names
- nanoparticle formulation of VERU-111MNP-VERU-111MNP-VERU111MNP-VERU 111
02
Targets
TUBB4A (β-tubulin 4A)TUBB3 (Tubulin beta-3 chain)
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