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MNS-FTD1
- Development stage
- Preclinical
- Lead developer
- Prediction BioSciences
- Modality
- Gene Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
MNS-FTD1 is an experimental therapeutic candidate being developed by Prediction BioSciences for the treatment of neurodegenerative conditions, including Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). The drug utilizes a proprietary exosome-based platform consisting of engineered neural exosomes loaded with nucleic acid vectors. This delivery system is designed for brain cell-type-specific targeting of pathways associated with progranulin (PGRN/GRN) mutations, C9orf72 gene mutations, and TDP-43 protein aggregation. MNS-FTD1 is currently in the preclinical stage of development, specifically undergoing candidate optimization.
02
Targets
GRN (Progranulin)C9orf72 (C9orf72 hexanucleotide repeat expansion and transcripts)TARDBP (TAR DNA-binding protein 43)
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