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Drug intelligence / Profile preview
MnTBAP
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
MnTBAP is a cell-permeable synthetic manganic porphyrin complex that functions as a superoxide dismutase (SOD) mimetic and a potent peroxynitrite scavenger. It exhibits broad-spectrum antioxidant and anti-inflammatory properties by reducing various reactive oxygen species (ROS) and reactive nitrogen species (RNS), including superoxide, hydrogen peroxide, and peroxynitrite. This compound has been investigated in preclinical models for its protective effects against oxidative stress and inflammation in conditions such as chronic renal failure, cisplatin-induced acute kidney injury, lung contusion, and Hutchinson-Gilford Progeria Syndrome. Its anti-inflammatory actions also involve the upregulation of Bone Morphogenetic Protein Receptor Type 2 (BMPR-II) and inhibition of NFκB, p38, and SAPK/JNK signaling pathways.
- Other names
- Mn(III)tetrakis(4-benzoic acid)porphyrin ChlorideMn(III)TBAP (chloride)MnTBAP chloride
02
Targets
NO2- (Nitrite)AKT (RAC-alpha serine/threonine-protein kinase)BMPR2 (Bone morphogenetic protein receptor type II)NOS3 (eNOS)MFN1 (Mitofusin-1)NF-κBJNK (Mitogen-activated protein kinase kinase kinase family)MAPK14 (p38 mitogen-activated protein kinase alpha)
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