Drug intelligence / Profile preview

modafinil + paracetamol

Development stage
Unknown
Lead developer
Teva Pharmaceutical Industries
Modality
Small Molecules
Administration
Oral, Intravenous, Rectal, Intramuscular
01

Overview

This is a combination of two active pharmaceutical ingredients: modafinil and paracetamol (also known as acetaminophen). Modafinil is a wakefulness-promoting agent primarily used to treat excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It acts as a central nervous system stimulant with mechanisms that are not fully understood but are believed to involve modulation of various neurotransmitter systems including dopamine reuptake inhibition. Paracetamol is an analgesic and antipyretic agent widely used for the relief of mild to moderate pain and fever; its mechanism involves inhibition of prostaglandin synthesis in the central nervous system. There is no evidence that this specific combination exists as a marketed fixed-dose product; however, both drugs may be co-administered in clinical practice for their respective indications.

Other names
modafinil and paracetamolmodafinil plus paracetamolmodafinil acetaminophen combination
02

Targets

SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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