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modakafusp alfa + carfilzomib
- Development stage
- Discontinued
- Lead developer
- Takeda
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Cytokines & Interferons → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This is a combination therapy of **modakafusp alfa** (previously TAK-573) and **carfilzomib** being investigated for the treatment of relapsed/refractory multiple myeloma. **Modakafusp alfa** is a first-in-class immunocytokine fusion protein consisting of two attenuated interferon alfa-2b molecules fused to a humanized anti-CD38 IgG4 monoclonal antibody. It specifically targets CD38-expressing myeloma cells, delivering interferon-alpha directly, inducing tumor cell death through anti-proliferative and pro-apoptotic signals and immune activation. **Carfilzomib** is a second-generation selective proteasome inhibitor; it inhibits the chymotrypsin-like activity of the 20S proteasome, leading to apoptosis of myeloma cells. The combination aims to leverage immune-targeted cytokine delivery and proteasome inhibition for synergistic anti-myeloma effects. The combination is currently being evaluated primarily in patients with relapsed/refractory multiple myeloma.
- Other names
- modakafusp alfa + carfilzomib
02
Targets
PSMB5 (Proteasome subunit beta Type-5)PSMB7 (Proteasome subunit beta type-7)CD38 (Cluster of Differentiation 38)IFNAR (Immune system modulation via type I interferon receptor)
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