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ModCAR-GRP78
- Development stage
- Preclinical
- Lead developer
- Hauul Bio
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
ModCAR-GRP78 is a modular chimeric antigen receptor (CAR) cell therapy being developed by Hauul Bio for the treatment of solid tumors, including triple-negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and colorectal cancer (CRC). The therapy utilizes a modular CAR platform designed to target GRP78 (Glucose-Regulated Protein 78), a chaperone protein that is typically located in the endoplasmic reticulum but becomes overexpressed on the surface of various cancer cells. By targeting surface-expressed GRP78, ModCAR-GRP78 aims to selectively eliminate tumor cells while minimizing off-target effects. The program is currently in the preclinical stage of development.
- Other names
- ModCAR-GRP78ModCAR-GRP-78ModCAR-GRP 78
02
Targets
HSPA5 (Heat shock protein family A member 5)
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