Drug intelligence / Profile preview

modified baihu tang

Development stage
Unknown
Lead developer
China Academy of Chinese Medical Sciences
Administration
Oral
01

Overview

Modified Baihu Tang is a Traditional Chinese Medicine (TCM) formula derived from the classic Baihu Tang (White Tiger Decoction). The base formula consists of Gypsum fibrosum, Rhizoma Anemarrhenae, Radix Glycyrrhizae, and Semen Oryzae Sativae. Modifications typically involve adding herbs like Radix Rehmanniae or Radix Trichosanthis to enhance its heat-clearing and fluid-engendering properties. It is primarily used to treat conditions characterized by "excessive heat," such as Type 2 Diabetes Mellitus (T2DM), acute febrile diseases, and inflammatory conditions. Its mechanism involves regulating glucose metabolism, reducing systemic inflammation, and modulating the gut microbiota. Pharmacological studies suggest it acts by inhibiting pro-inflammatory cytokines and activating metabolic pathways like AMPK.

Other names
白虎汤化裁方Modified White Tiger DecoctionBaihu Tang Huacai Fang
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))

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