Drug intelligence / Profile preview

modified buzhong yiqi decoction

Development stage
Preclinical
Lead developer
Guangdong Provincial Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Modified Buzhong Yiqi Decoction is a Traditional Chinese Medicine (TCM) herbal formulation derived from the classic Buzhong Yiqi Decoction, specifically adapted for the treatment of benign prostatic hyperplasia (BPH) and detrusor hypofunction (underactive bladder). Developed and utilized by clinicians at Fangcun Hospital (a branch of the Guangdong Provincial Hospital of Traditional Chinese Medicine), the formula is designed to address the TCM pattern of "Spleen-Qi deficiency" and "sunken Yang," which are thought to contribute to poor bladder contractility and urinary retention. The modification typically involves the addition of specific herbs that promote diuresis and improve the myogenic tone of the detrusor muscle. It is frequently employed as a post-operative recovery aid for patients undergoing transurethral resection of the prostate (TURP) who continue to experience voiding dysfunction due to detrusor underactivity.

Other names
Jiawei Buzhong Yiqi DecoctionModified Tonifying Middle and Augmenting Qi DecoctionJiawei Buzhong Yiqi Tang
02

Targets

IL1B (Interleukin-1 beta)RORγtAKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)IL-6 (Interleukin 6)CASP3 (Caspase-3)

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