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modified Chaihu Jia Longgu Muli Decoction
- Development stage
- Unknown
- Lead developer
- Huzhou Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Modified Chaihu Jia Longgu Muli Decoction is a traditional Chinese medicine (TCM) formula derived from the classic "Chaihu Jia Longgu Muli Decoction" (Bupleurum plus Dragon Bone and Oyster Shell Decoction). It is being investigated as an adjunctive therapy for Parkinson's disease complicated by rapid eye movement sleep behavior disorder (RBD). The formula typically aims to soothe the liver, clear heat, and calm the spirit (Shen). In the context of Parkinson's disease, it is hypothesized to modulate the central nervous system, potentially influencing melatonin levels and improving both motor and non-motor symptoms like sleep disturbances. The "modified" version used by Huzhou Hospital of Traditional Chinese Medicine likely includes specific herbal adjustments tailored to the neurodegenerative and sleep-related pathology of Parkinson's patients.
- Other names
- Modified Chaihu Jia Longgu Muli TangModified Bupleurum plus Dragon Bone and Oyster Shell Decoction
02
Targets
LGALS3 (Galectin-3)MTNR1A (MT1)NMDAR (Glutamate receptor ionotropic, NMDA)HCRTR1 (Orexin/hypocretin receptor type 1)
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