modified chitosan

Modified chitosan in this context refers to a medical-grade, chemically altered derivative of the natural polysaccharide chitosan, designed for intra-articular injection. It serves as a biomimetic synovial fluid (viscosupplement) for the treatment of knee osteoarthritis, particularly in patients with cartilage defects. By mimicking the rheological and lubricating properties of healthy synovial fluid, it aims to reduce joint friction, alleviate pain, and potentially provide a protective environment for articular cartilage. The modification of the chitosan backbone is typically performed to improve its solubility at physiological pH and to optimize its viscoelastic properties for joint lubrication.

Other names

medical modified chitosanbiomimetic synovial fluidmodified medical chitosan