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modified danggui-shaoyao san
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Modified Danggui-Shaoyao San is an herbal formula based on the classical traditional Chinese medicine prescription Danggui Shaoyao San, a combination of six herbs: Angelica sinensis (danggui), Paeonia lactiflora (baishao), Ligusticum chuanxiong (chuanxiong), Poria cocos (fuling), Alisma orientalis (zexie), and Atractylodes macrocephala (baizhu)[1][2][3]. It is commonly used for gynecological conditions such as menstrual disorders, dysmenorrhea, and other deficiency-related disorders, but also shows promise for neurological diseases such as Alzheimer's disease, due to its anti-inflammatory and antioxidant effects, modulation of multiple neurotransmitter systems, and gut microbiota regulation[2][3][5]. The "modified" version refers to variations in dosage or substitution/addition of ingredients tailored to specific patient presentations, typical in clinical TCM practice.
- Other names
- modified danggui-shaoyao san
02
Targets
AMPK/mTOR axis (AMPK / mTOR signaling axis)NFKB1 (NF-κB1)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)IL-6 (Interleukin 6)
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