modified dual therapy

Modified dual therapy is a combination regimen used primarily for the eradication of Helicobacter pylori infection. It typically consists of a high dose of a proton pump inhibitor (PPI) and amoxicillin, administered at increased doses and frequency compared to standard regimens. The approach aims to improve eradication rates while minimizing side effects and costs relative to more complex therapies such as bismuth-containing quadruple therapy. Modified dual therapy has demonstrated similar efficacy (eradication rates around 88–91%) compared with quadruple regimens but with fewer adverse events and better patient tolerance. The mechanism involves suppression of gastric acid secretion by the PPI, enhancing the bactericidal activity of amoxicillin against H. pylori[1][2][3].

Other names

modified dual therapyhigh-dose dual therapyHDDT