Modified Early Post-Operative Intraperitoneal Chemotherapy

Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC) is a chemotherapy regimen designed to maximize therapeutic benefit and reduce logistical barriers compared to standard Early Post-Operative Intraperitoneal Chemotherapy (EPIC). The regimen shortens the postoperative intraperitoneal chemotherapy from five to two days. It involves administering one intraperitoneal bolus of fluorouracil (5-FU) at 400 mg/m2, followed by a 24-hour intraperitoneal infusion of 5-FU at 1200 mg/m2, on postoperative days 1 and 2. This approach aims to exploit the known pharmacokinetics and pharmacodynamics of 5-FU, which primarily acts by inhibiting thymidylate synthase, while improving feasibility and patient management. It is being investigated for the treatment of peritoneal carcinomatosis arising from colorectal and appendicular neoplasms.

Other names

modified schedule of EPIC