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Modified Ershen Pill
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Modified Ershen Pill is a traditional Chinese medicine formulation derived from the original "Ershen Pill" (ESP). It is primarily studied for its effects on Pi (Spleen)-Shen (Kidney) yang deficiency-induced diarrhea, a syndrome recognized in traditional Chinese medicine. In preclinical studies using rat models, extracts of the pill have been shown to alleviate symptoms such as diarrhea and weight loss by improving aquaporin-3 (AQP3) synthesis in the colon. This suggests that its mechanism involves modulation of water transport and intestinal function via upregulation of AQP3 expression. The formulation typically contains multiple herbal ingredients, but specific composition details for "Modified Ershen Pill" are not provided in available sources[4].
- Other names
- Ershen PillESP
02
Targets
AQP3 (Aquaporin-3 channel protein)
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