modified FOLFOXIRI

Modified FOLFOXIRI is a chemotherapy regimen that combines folinic acid (leucovorin), fluorouracil (5-FU), oxaliplatin, and irinotecan. It is used primarily for the treatment of metastatic colorectal cancer. The "m" prefix likely indicates a modification to the standard FOLFOXIRI dosing regimen. The standard FOLFOXIRI regimen works through multiple mechanisms: fluorouracil inhibits DNA synthesis, oxaliplatin forms DNA adducts resistant to repair, and irinotecan inhibits topoisomerase I. Folinic acid is not a chemotherapy drug but enhances the efficacy of fluorouracil. The modified regimen is typically administered every 14 days (2 weeks) and may be combined with biological agents such as bevacizumab.

Other names

mFOLFOXIRIfluorouracil-Al-Azhar University-metastatic colorectal cancer