Drug intelligence / Profile preview

modified Ganmai Dazao Decoction

Development stage
Unknown
Lead developer
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
Administration
Oral
01

Overview

Modified Ganmai Dazao Decoction is a Traditional Chinese Medicine (TCM) herbal formula derived from the classic Ganmai Dazao Decoction, which traditionally consists of *Glycyrrhizae Radix* (Gan Cao), *Tritici Fructus Levis* (Xiao Mai), and *Jujubae Fructus* (Da Zao). This modified version is specifically being investigated by the Yueyang Integrated Traditional Chinese and Western Medicine Hospital for the treatment of tumor-associated sleep disorders (insomnia) in cancer patients. The formula is hypothesized to improve sleep quality and regulate neuroendocrine function, potentially by modulating neurotransmitters such as GABA or serotonin, although the exact molecular targets of the multi-herb mixture are complex. In clinical trials, it is often used as an adjuvant therapy alongside standard sedative-hypnotic medications.

Other names
modified Ganmai Dazao TangJiajian Ganmai Dazao Decoctionmodified Gan Mai Da Zao Tang
02

Targets

BDNF (Brain-derived neurotrophic factor)MAPK14 (p38 mitogen-activated protein kinase alpha)NTRK2 (Tropomyosin-related kinase receptor type B)

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