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Modified Gengnianchun Formula
- Development stage
- Unknown
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Modified Gengnianchun Formula is a traditional Chinese medicine (TCM) herbal combination, derived from the original Gengnianchun recipe and further modified to enhance its therapeutic effects. It is primarily used for the treatment of diminished ovarian reserve (DOR), menopausal syndrome, and stress-induced reproductive dysfunction. The formula has demonstrated efficacy in alleviating symptoms such as hot flushes, depression, anxiety, and sleep disturbances in peri- and postmenopausal women. Experimental studies suggest that its mechanism involves modulation of oxidative stress pathways—particularly through the PI3K-Akt signaling pathway—and improvement of ovarian function by reducing granulosa cell senescence. The formula does not significantly affect serum follicle-stimulating hormone or estradiol levels but improves quality of life with minimal adverse effects[1][5][8].
- Other names
- Bushen Shugan Huoxue formulaImproved Gengnianchun (I-GNC)
02
Targets
FOXO1 (Forkhead box protein O1)AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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