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Modified HUCB cells
- Development stage
- Preclinical
- Lead developer
- Kazan State Medical University
- Modality
- Gene Editing → Gene Therapies, Gene Silencing → Gene Therapies, Gene Addition/Replacement → Gene Therapies, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Modified HUCB cells are human umbilical cord blood cells that have been genetically engineered to express specific therapeutic genes, namely vascular endothelial growth factor (VEGF) and L1 cell adhesion molecule (L1CAM). These modified cells are designed to act as a delivery system for neuro-trophic and neuro-protective factors, supporting neuro-genesis and promoting axon guidance, outgrowth, and fasciculation. They are being investigated as a novel stem cell therapy approach for neuro-degenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), by transforming into vascular endothelial cells and secreting beneficial factors rather than differentiating into neurons. Genetic modification enhances the ability of these cells to regenerate tissue, combining the advantages of cell and gene therapy.
- Other names
- Human umbilical cord blood cells transfected with VEGF and L1CAM
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