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modified process hepatitis b vaccine
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Modified Process Hepatitis B Vaccine (mpHBV) is a recombinant protein subunit vaccine developed by Merck Sharp & Dohme (MSD) for the prevention of hepatitis B infection. It represents a next-generation optimization of the standard RECOMBIVAX HB vaccine, utilizing a modified manufacturing process that features a higher phosphate content in the aluminum-based adjuvant to enhance consistency and immunogenicity. The vaccine's active ingredient is the hepatitis B surface antigen (HBsAg), which is designed to induce protective serum antibodies (anti-HBs) in the recipient. Clinical development has included Phase 3 trials in healthy infants, neonates, and adults, where it demonstrated a safety and immunogenicity profile comparable to the original formulation.
- Other names
- Modified Process Hepatitis B VaccinempHBV vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)
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