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Modified Qing-Zao-Jiu-Fei Decoction
- Development stage
- Phase 2
- Lead developer
- The Chinese University of Hong Kong
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Modified Qing-Zao-Jiu-Fei Decoction (MQZJFD) is a traditional Chinese herbal formula developed for the treatment of chronic pulmonary diseases, specifically pneumoconiosis and pulmonary fibrosis. It is an optimized version of the classical Qing-Zao-Jiu-Fei Decoction (QZJFD), enhanced by the addition of *Trichosanthis Fructus* (TF) and *Fritillariae Thunbergii Bulbus* (FTB). The formulation contains several bioactive markers, including amygdalin, glycyrrhizic acid, and chlorogenic acid. MQZJFD acts by modulating several key signaling pathways involved in inflammation and fibrosis; specifically, it upregulates the Nrf2 antioxidant pathway while suppressing the NF-κB and MAPK (including ERK, p38, and JNK) pathways. This multi-target approach results in the reduction of oxidative stress, collagen deposition, and the expression of fibrotic biomarkers such as matrix metalloproteinase 9 (MMP9) and alpha-smooth muscle actin (α-SMA).
- Other names
- Modified Qing Zao Jiu Fei Decoction
02
Targets
MMP9 (Matrix metalloproteinase-9)JNK (Mitogen-activated protein kinase kinase kinase family)MAPK3 (Mitogen-activated protein kinase 1)RK (Ribokinase)
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