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Modified Rou Gan San Jie Fang is a Traditional Chinese Medicine (TCM) herbal formula developed for the treatment of liver cirrhosis and chronic hepatitis B virus infection. The formula is designed based on the TCM principles of "softening the liver" (Rou Gan) and "dissipating nodules" (San Jie) to address hepatic fibrosis and the structural changes associated with cirrhosis. It is currently being evaluated in clinical trials, such as ChiCTR2400086773, as an adjunctive therapy to standard antiviral treatments like tenofovir alafenamide. The "modified" version typically involves a specific combination of herbs tailored by the Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine to optimize anti-fibrotic and hepatoprotective effects in patients with post-hepatitis B liver cirrhosis.
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