Drug intelligence / Profile preview

modified Scutellaria decoction

Development stage
Unknown
Lead developer
Eighth People's Hospital of Shanghai
Administration
Oral
01

Overview

Modified Scutellaria decoction is a Traditional Chinese Medicine (TCM) herbal formulation based on the classical Huangqin Tang. It is being evaluated as an adjuvant therapy to standard chemotherapy (such as 5-fluorouracil and irinotecan) for patients with metastatic colorectal cancer, specifically those presenting with a damp-heat syndrome pattern. The decoction typically contains *Scutellaria baicalensis* as its primary ingredient, which is known for its anti-inflammatory and potential anti-tumor properties. In the context of oncology, it is used to improve quality of life, reduce chemotherapy-induced gastrointestinal toxicity (such as diarrhea), and potentially enhance the efficacy of conventional treatments by modulating inflammatory pathways and the gut environment.

Other names
modified Huangqin Tangmodified Huang-Qin-Tangmodified Scutellaria baicalensis decoction
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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