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Modified Simiao Yong'an Soup
- Development stage
- Preclinical
- Lead developer
- Xiyuan Hospital
- Administration
- Oral
01
Overview
Modified Simiao Yong'an Soup is a traditional Chinese medicine (TCM) formula derived from the classic Simiao Yong'an Decoction. It is currently under investigation for the treatment of non-infectious uveitis. The base formula, Simiao Yong'an Decoction, is recognized for its multi-targeted therapeutic actions, including anti-inflammatory, anti-apoptotic, and immunomodulatory effects. It has been shown to modulate various signaling pathways involved in inflammation, cell survival, and angiogenesis. This herbal preparation is typically administered orally.
- Other names
- Modified Simiao Yong'an Soup Recipe GranulesSi-Miao-Yong-An DecoctionSMYAD
02
Targets
TLR4 (Toll-like receptor 4)VEGFA (Vascular endothelial growth factor A)MAPK3 (Mitogen-activated protein kinase 1)PDGFRB (Platelet-derived growth factor receptor beta)TGFB1 (Transforming growth factor Beta-1 proprotein)NF-κBCXCL2 (C-X-C motif chemokine ligand 2)ICAM1 (Intercellular Adhesion Molecule 1)IL8 (C-X-C Motif Chemokine Ligand 8)VEGFR2 (Vascular endothelial growth factor receptor 2)AGER (RAGE)AKT (RAC-alpha serine/threonine-protein kinase)JAK1 (Janus kinase 1)HDAC1 (Histone Deacetylase 1)HIF1A (Hypoxia-inducible factor 1-alpha)CCND1 (Cyclin D1)IL-6 (Interleukin 6)CCL2 (C-C motif chemokine 2)CXCL1 (C-X-C motif chemokine ligand 1)FGF2PI3K (Phosphoinositide-3-kinase regulatory subunit 6)VCAM1 (Vascular cell adhesion molecule 1)CDK4 (Cyclin-dependent kinase 4)PDE5 (Phosphodiesterase 5A)PPARG (Peroxisome proliferator-activated receptor gamma)MMP9 (Matrix metalloproteinase-9)IL1B (Interleukin-1 beta)TNFA (Tumor necrosis factor alpha (soluble))NOX4 (NADPH oxidase 4)ATM (Ataxia telangiectasia mutated protein)
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