Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
modified Simiao Yongan decoction
- Development stage
- Unknown
- Lead developer
- Chengdu University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Modified Simiao Yongan Decoction is a traditional Chinese medicine (TCM) herbal formula derived from the classic Simiao Yongan Decoction, which traditionally consists of Lonicera japonica (honeysuckle), Scrophularia ningpoensis (figwort), Angelica sinensis (Chinese angelica), and Glycyrrhiza uralensis (licorice). The modified formulation is being evaluated by the Chengdu University of Traditional Chinese Medicine for the treatment of diabetic foot ulcers (DFUs), particularly in patients presenting with damp-heat toxins accumulation syndrome. It is administered orally as a decoction, often in combination with standard endovascular therapy and wound care. The therapeutic mechanism of Modified Simiao Yongan Decoction involves promoting wound healing, improving peripheral nerve damage, enhancing angiogenesis, and regulating inflammation and oxidative stress, potentially through pathways such as METTL14/BECN1 and NLRP3 inflammasome inhibition.
- Other names
- Jiawei Simiao Yongan DecoctionMSMYAmodified Si-Miao-Yong-An decoction
02
Targets
BECN1 (Beclin-1)IL-6 (Interleukin 6)METTL14 (Methyltransferase like 14)MMP9 (Matrix metalloproteinase-9)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
Beyond the preview
Go deeper on modified Simiao Yongan decoction.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on modified Simiao Yongan decoction.