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modified XELIRI
- Development stage
- Unknown
- Lead developer
- Chugai Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Modified XELIRI (mXELIRI) is a combination chemotherapy regimen consisting of capecitabine and irinotecan, used primarily in the treatment of metastatic colorectal cancer and also studied in advanced gastric cancer. The "modified" aspect refers to reduced or adjusted dosing compared to the original XELIRI protocol, aiming to improve tolerability while maintaining efficacy. Capecitabine is an oral prodrug that is converted into 5-fluorouracil (5-FU) in the body, inhibiting thymidylate synthase and interfering with DNA synthesis. Irinotecan is a topoisomerase I inhibitor that prevents DNA unwinding and replication by stabilizing the cleavable complex between topoisomerase I and DNA, leading to cell death. Modified XELIRI has demonstrated non-inferior efficacy compared to FOLFIRI regimens in phase III trials for second-line treatment of metastatic colorectal cancer, with improved convenience due to oral administration of capecitabine and a favorable safety profile[1][3][4][5].
- Other names
- capecitabine plus irinotecan (modified regimen)mXELIRI
02
Targets
TOP1 (DNA Topoisomerase I)TS (Thymidylate synthase)
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