Drug intelligence / Profile preview

Modified Xiaoyao Powder + Tianwang Buxin Dan + Wendan Decoction + Night Jiaoteng + Fushen

Development stage
Unknown
Lead developer
Taipei Veterans General Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

Modified Xiaoyao Powder + Tianwang Buxin Dan + Wendan Decoction + Night Jiaoteng + Fushen is a multi-component Traditional Chinese Medicine (TCM) herbal combination therapy being evaluated by Taipei Veterans General Hospital for the treatment of primary insomnia. The regimen consists of three classic TCM formulas: Modified Xiaoyao Powder (Jia Wei Xiao Yao San), which is traditionally used to soothe the liver and nourish blood; Tianwang Buxin Dan, aimed at nourishing the heart and calming the spirit; and Wendan Decoction, used to clear heat and transform phlegm. These are supplemented with the individual herbs Night Jiaoteng (Caulis Polygoni Multiflori) and Fushen (Poria cum Radix Pini) for their specific sedative and spirit-calming properties. In clinical trial protocols, this oral herbal mixture is administered twice daily and is often paired with auricular point stimulation (using magnetic beads at the Shenmen, heart, and brainstem points) to enhance therapeutic efficacy. The formulation is manufactured by Keda GMP Pharmaceutical Factory and is intended to provide a holistic alternative to conventional sedative-hypnotics, aiming to avoid side effects such as dependency, tolerance, and daytime drowsiness.

Other names
Modified Xiaoyao Powder-Taipei Veterans General Hospital, Taiwan-primary insomniaJia Wei Xiao Yao San combinationTCM for Primary Insomnia regimenModified Xiaoyao PowderTianwang Buxin DanWendan DecoctionNight JiaotengFushen
02

Targets

GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)

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