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Modified Xinglou Chengqi Granules
- Development stage
- Phase 1
- Lead developer
- Traditional Chinese Medicine Hospital of Southwest Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Modified Xinglou Chengqi Granules (also known as Jiawei Xinglou Chengqi Granules) is a traditional Chinese medicine (TCM) herbal formulation developed by the Traditional Chinese Medicine Hospital of Southwest Medical University. It is a modified version of the classic Xinglou Chengqi Decoction, which is traditionally used to treat stroke and related complications. The formulation is being evaluated in clinical trials for the treatment of acute stroke, including acute ischemic stroke and intracerebral hemorrhage, to assess its efficacy, safety, and potential mechanisms of action, such as modulating the gut microbiota and reducing neuronal damage.
- Other names
- Jiawei Xinglou Chengqi GranuleJiawei Xinglou Chengqi Granules加味星蒌承气颗粒
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)IL1B (Interleukin-1 beta)PRKCE (Protein Kinase C epsilon)PRKCH (Protein kinase C eta)PRKCQ (Protein kinase C theta)STAT3 (Signal Transducer and Activator of Transcription 3)VEGFA (Vascular endothelial growth factor A)
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