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modified Zhiwang decoction
- Development stage
- Phase 1
- Lead developer
- Beijing Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Modified Zhiwang Decoction (MZWD) is a Traditional Chinese Medicine (TCM) herbal formula primarily researched for the treatment of early Rheumatoid Arthritis (RA). The decoction is a specialized formulation derived from the 'Zhiwang' base, which typically centers on the medicinal properties of *Anemarrhena asphodeloides* (Zhimu) and *Rehmannia glutinosa* (Diwang). In clinical practice, MZWD is used to address the 'damp-heat' and 'toxin' patterns associated with joint inflammation and bone destruction in RA patients. The pharmacological profile of the decoction involves complex immunomodulatory and anti-inflammatory actions, which are believed to suppress the production of pro-inflammatory cytokines and regulate the immune response. It is frequently evaluated as a combination therapy alongside conventional disease-modifying antirheumatic drugs (DMARDs) like methotrexate to improve clinical efficacy and reduce systemic inflammation markers.
- Brand names
- simiaoxiaoling zhiwang decoction
- Other names
- modified Zhiwang tangZhiwang decoction
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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