Drug intelligence / Profile preview

modipafant

Development stage
Preclinical
Lead developer
60 Degrees Pharmaceuticals
Modality
Small Molecules
Administration
Oral, Inhalation, Intravenous
01

Overview

Modipafant is a small molecule drug that acts as a potent and selective antagonist of the platelet-activating factor receptor (PAF receptor). The PAF receptor is involved in various biological processes, including inflammation, immune responses, and platelet aggregation. By blocking this receptor, modipafant inhibits downstream signaling pathways that contribute to inflammatory responses and platelet aggregation. Modipafant has been studied for its potential applications in treating inflammatory diseases and conditions related to platelet activation, such as asthma and allergic diseases. It is classified chemically as a dihydropyridine PAF antagonist with lipophilic properties[6][8].

02

Targets

PTAFR (Platelet-activating factor receptor)

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