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MOG196-NPs
- Development stage
- Preclinical
- Lead developer
- Long Island University
- Modality
- Peptides, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
MOG196-NPs is an investigational nanoparticle-based immunotherapy consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) nanoparticles encapsulating MOG196, a myelin oligodendrocyte glycoprotein peptide epitope, along with a dendritic cell (DC) activator and an MHC-E enhancer. Developed by TangGene and Long Island University, MOG196-NPs are designed to target and activate dendritic cells in vivo, promoting the presentation of the MOG196 peptide by nonclassical MHC class Ib molecules (HLA-E in humans and Qa-1 in mice). This presentation selectively stimulates and expands myelin-specific, MHC-E-restricted regulatory CD8 T cells (CD8 Tregs), which in turn suppress pathogenic autoreactive CD4 T cells. MOG196-NPs is being developed as a potential preventive and curative treatment for multiple sclerosis.
- Other names
- MOG196 nanoparticlesMOG-196 nanoparticlesMOG 196 nanoparticlesMOG196-NPMOG-196-NPMOG 196-NP
02
Targets
HLA-E (Human leukocyte antigen-e)MOG (Myelin oligodendrocyte glycoprotein)
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